1-Propanoyl-lysergic acid diethylamide (1P-LSD)

1P-LSD

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	379.5 g/mol ^[1]
Predicted LogP	3.3 ^[1]

Structural Identifiers []
Molecular formula	C₂₃H₂₉N₃O₂ ^[1]
IUPAC name	(6aR,9R)-N,N-diethyl-7-methyl-4-propanoyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide ^[1]
SMILES	CCC(=O)N1C=C2C[C@@H]3C(=C[C@H](CN3C)C(=O)N(CC)CC)C4=C2C1=CC=C4 ^[1]
InChI	InChI=1S/C23H29N3O2/c1-5-21(27)26-14-15-12-20-18(17-9-8-10-19(26)22(15)17)11-16(13-24(20)4)23(28)25(6-2)7-3/h8-11,14,16,20H,5-7,12-13H2,1-4H3/t16-,20-/m1/s1 ^[1]
InChIKey	JSMQOVGXBIDBIE-OXQOHEQNSA-N ^[1]

Pharmacokinetics[]
Elimination half-life	Initial: ~0.2 hours
Duration of action	8 – 12 hours

1-Propanoyl-lysergic acid diethylamide (also known as 1-Propionyl-lysergic acid diethylamide, 1-Propionyl-lsd, 1P-LSD, 1P-LAD, N,N-Diethyl-7-methyl-4-propanoyl-6,6a,8,9-tetrahydroindolo(4,3-fg)quinoline-9-carboxamide, Schembl24635597, Schembl29557113, NS00096729 or N,N-Diethyl-6-methyl-1-propanoyl-9,10-didehydroergoline-8β-carboxamide) is a psychedelic substance of the lysergamide class.

Chemistry

Stereochemistry []

1-Propanoyl-lysergic acid diethylamide is a absolute mixture.

Subjective effects []

Experience reports

a1ko / 1-Propanoyl-lysergic acid diethylamide []
Routes: Sublingual

emily / 1-Propanoyl-lysergic acid diethylamide []
Routes: Oral (75 - 150μg)

There are currently 45 trip reports involving 1-propanoyl-lysergic acid diethylamide on Reddit: []

Legal status []

Australia: 1-Propanoyl-lysergic acid diethylamide is a S8 substance.
Brazil: 1-Propanoyl-lysergic acid diethylamide is a F2 substance.
Canada: 1-Propanoyl-lysergic acid diethylamide is a Unscheduled..
Germany: 1-Propanoyl-lysergic acid diethylamide is a Neuer-Psychoaktiver-Stoff under the "Neue-psychoaktive-Stoffe-Gesetz (NpSG)".
United Kingdom: 1-Propanoyl-lysergic acid diethylamide is a PSA substance.
United States: 1-Propanoyl-lysergic acid diethylamide is a Unscheduled (may be considered illegal if sold for human consumption as an analog of LSD under the federal analogue act) substance.
United Nations: 1-Propanoyl-lysergic acid diethylamide is a Unscheduled substance.

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 119025985, 1-Propanoyl-lysergic acid diethylamide. Accessed August 22, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/119025985
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. 1-Propanoyl-lysergic acid diethylamide. UNII: 23R2G2G79C. Global Substance Registration System. Accessed August 22, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/23R2G2G79C

AnodyneWiki

1-Propanoyl-lysergic acid diethylamide